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Description
PVRIG Fc Chimera Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms PVRIGPVR Related Immunoglobulin Domain ContainingCD112 ReceptorPoliovirus Receptor Related Immunoglobulin Domain Containing ProteinPoliovirus Receptor Related Immunoglobulin Domain ContainingNectin 2 ReceptorC7orf15CD112RTransmembrane Protein PVRIGMGC2463 Accession A0A2K5WVV8 Amino Acid Sequence Thr41 Asp171, with C terminal Fc Expression System HEK293 Molecular Weight 45 50kDa (Reducing) Purity 95% by
Product Specification
| Species | Cynomolgus |
| Synonyms | PVRIG，PVR Related Immunoglobulin Domain Containing，CD112 Receptor，Poliovirus Receptor-Related Immunoglobulin Domain-Containing Protein，Poliovirus Receptor Related Immunoglobulin Domain Containing，Nectin-2 Receptor，C7orf15，CD112R，Transmembrane Protein PVRIG，MGC2463 |
| Accession | A0A2K5WVV8 |
| Amino Acid Sequence | Thr41-Asp171, with C-terminal Fc |
| Expression System | HEK293 |
| Molecular Weight | 45-50kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Zhu, Y., et.al. (2016) J. Exp. Med. 213:167. |
Background
Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein) is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. PVRIG (poliovirus named receptor-related immunoglobulin domain-containing), also known as CD112R, is a novel member of the PVR-like co-signaling network. The human CD112R intracellular domain comprises two tyrosine residues, one of which is part of an ITIM-like motif and a potential site for phosphatases. In humans, CD112R is expressed on T cells (predominantly CD8+ T cells) and natural killer (NK) cells, but not on B cells, monocytes or neutrophils. PVRIG binds to a single ligand, poliovirus receptor-related 2 (PVRL2, also known as CD112 or Nectin-2), and exerts an inhibitory effect on cytotoxic lymphocyte activity, likely via an ITIM-like motif in its intracellular domain. CD112R transduces signals by recruiting tyrosine phosphatases. Additionally, CD112R potentially represents a new coinhibitory receptor that suppresses T cell receptor-mediated NFAT activation.
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