SKU: 3162844118

Kupfertoxikose (CT) - Labrador Retriever

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Description

Kupfertoxikose (CT) - Labrador RetrieverStoffwechselstrungen des Kupfers sind genetische Strungen des Kupferstoffwechsels in der Leber, die durch Mutationen in zwei Genen verursacht werden, die Kupfertransporter kodieren ATP7A und ATP7B. Der ATP7A Transporter ist entscheidend fr den Kupfertransport von Fibroblasten in die Leber und der ATP7B ist entscheidend fr den Kupferexport aus der Leber. Mutationen im ATP7A fhren zu einem defekten ATP7A Transporter, sodass das Kupfer nicht richtig aus

Stoffwechselstörungen des Kupfers sind genetische Störungen des Kupferstoffwechsels in der Leber, die durch Mutationen in zwei Genen verursacht werden, die Kupfertransporter kodieren – ATP7A und ATP7B. Der ATP7A-Transporter ist entscheidend für den Kupfertransport von Fibroblasten in die Leber und der ATP7B ist entscheidend für den Kupferexport aus der Leber. Mutationen im ATP7A führen zu einem defekten ATP7A-Transporter, sodass das Kupfer nicht richtig aus den Fibroblasten exportiert und in die Leber importiert werden kann, was zu einem Kupfermangel in der Leber führt. Dies führt zu Menkes-Krankheit, einer tödlichen neurodegenerativen Erkrankung, die durch zerebrale und zerebelläre Degeneration, Gedeihstörung, grobes Haar und Bindegewebsanomalien gekennzeichnet ist. Währenddessen führen die Mutationen im ATP7B-Gen zu einem defekten ATP7B-Transporter, sodass das Kupfer nicht richtig aus der Leber exportiert werden kann, was zu einer Kupferansammlung in der Leber und sekundär im Gehirn führt. Dies führt zu Morbus Wilson, was bei mittelalten Hunden zu Zirrhose und neuronaler Degeneration führt. Die Mutation im ATP7A-Gen hat eine X-chromosomale Vererbung und die Mutation im ATP7B-Gen hat eine unvollständig dominante Vererbung. Störungen treten bei Labrador Retrievern und Dobermann Pinschern auf. Bei Dobermann Pinschern werden jedoch Mutationen in beiden Genen gefunden, aber nur die Mutation im ATP7B kann zu einer Störung führen, in diesem Fall Morbus Wilson. Bei Labrador Retrievern können Mutationen nur in einem oder in beiden Genen gleichzeitig vorhanden sein. Mutationen in beiden Genen gleichzeitig können zu einer abnorm hohen Kupferansammlung führen, die zu Kupfertoxikose führt, insbesondere bei Hündinnen.

Vererbung: komplex

Mutation: ATP7A und ATP7B Gen

Gentest: Die Methode, die für den Gentest verwendet wird, ist äußerst genau und ermöglicht eine vollständige Unterscheidung zwischen betroffenen Tieren, Trägern und gesunden Hunden. DNA-Tests können in jedem Alter durchgeführt werden.

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SKU: 3162844118

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4.2 ★★★★★
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Shawn SnoMan Thompson
Port Orchard, US
★★★★★ 5
For work or casual wear, this polo is a great choice.
Material Type: Recycled Polyester, Color: Port Stripe, Size: X-Large
I really like this polo. I've been wearing it once a week or every other week since November. Its very comfortable and breathable. This polo feels like it should last a while. The fit is good. I typcally wear XL and this XL fits great. I've pruchased it in both burgundy and black so far. I definitely recommend this shirt. For work or casual wear, this will look good.
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Reviewed in the United States on January 11, 2026
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Tech Dad
West Palm Beach, US
★★★★★ 5
Great value: These are my go-to work from home shirt
Material Type: Recycled Polyester, Color: Blue, Size: X-Large
I’ve been pleasantly surprised by these shirts and wear them weekly for Zoom calls, since I’m still working from home these days. I figured at the price point it was worth trying them out, and now I’ve bought several in different colors. They aren’t super soft, but they are comfy and look nice. I’m 6’1” ~220 pounds, and the XL slim fit still has plenty of room. I imagine the regular cut is incredibly boxy and oversized. The difference between polyester vs recycled polyester is inconsequential. I typically buy expensive golf shirts, and these definitely aren’t as nice. They are a fraction of the cost though and a great “beater” work shirt / hang out shirt. It’s nice wearing something that looks and feels decent, but if something happens to it, you can toss and it and pick up another for the cost of a chipotle burrito.
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Reviewed in the United States on May 29, 2022
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Espresso
Los Angeles, US
★★★★★ 3
Great price, not great quality
Material Type: Recycled Polyester, Color: Black, Size: Small
Simple, straight forward all black polo. I am a size medium woman (with some room since I don't like form-fitting) and bought a men's small. Fits perfectly for my frame. Long enough to tuck in for my part-time extra weekend job uniform. Also suitable for the golf course. A little thin, and if you hold it up to light you can sort of see through it. *Not* flowy, soft and smooth fabric like a rash guard/sun shirt - more structured than that. But it's cool and does the job for the price under $10.
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Reviewed in the United States on August 13, 2024
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Ken Strech
Louisville, US
★★★★★ 5
Recommend
Material Type: Recycled Polyester, Color: Dark Navy, Size: X-Large
Great fit, right price
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Reviewed in the United States on March 18, 2026
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Gwen
Louisville, US
★★★★★ 5
Nice polo
Material Type: Recycled Polyester, Color: Dark Teal, Size: Medium
Fantastic polo shirt. Size was true to fit. Color is amazing. It’s soft and it has held up through washes since Christmas.
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Reviewed in the United States on March 14, 2026

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